| Bioactivity | Hippeastrine, an active alkaloid, exhibits a good dose-dependent inhibitory effect against topoisomerase I (Top I) with an IC50 at 7.25 μg/mL. Antiproliferative and anticancer activities[1]. |
| Invitro | Hippeastrine strongly inhibits the proliferation of HT-29 and Hep G2 cells in an intuitive dose-dependent manner with the IC50s at 3.98 μg/mL and 11.85 μg/mL, respectively, and also induces significant cellular morphological changes, which further validate our screening method and the potent antineoplastic effects[1]. |
| Name | Hippeastrine |
| CAS | 477-17-8 |
| Formula | C17H17NO5 |
| Molar Mass | 315.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chen GL, et al. Antiproliferative activities of Amaryllidaceae alkaloids from Lycoris radiata targeting DNA topoisomerase I. Sci Rep. 2016;6:38284. Published 2016 Dec 6. |