| Bioactivity | Coleon-U-quinone is a potent P-gp inhibitor. Coleon-U-quinone can inhibit cancer cells viability and sensitize multidrug resistance cancer cells to Doxorubicin (HY-15142A)[1]. |
| Target | P-glycoprotein |
| Invitro | Coleon-U-quinone (0-50 μM; 72 h) has inhibitory activity against NCI-H460, NCI-H460/R and MRC-5[1].Coleon-U-quinone (1-5 μM; 72 h) sensitize NCI-H460/R cells to Doxorubicin (HY-15142A)[1]. Cell Viability Assay[1] Cell Line: |
| Name | Coleon-U-quinone |
| CAS | 65714-83-2 |
| Formula | C20H24O5 |
| Molar Mass | 344.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ntungwe EN, et al. C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators. ACS Med Chem Lett. 2022 Mar 11;13(4):674-680. |
Coleon-U-quinone
CAS: 65714-83-2 F: C20H24O5 W: 344.40
Coleon-U-quinone is a potent P-gp inhibitor. Coleon-U-quinone can inhibit cancer cells viability and sensitize multidrug
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