| Bioactivity | HUP30 is a vasodilating agent. HUP30 stimulates soluble guanylyl cyclase, activate K+ channels, and blocks extracellular Ca2+ influx[1]. | ||||||||||||
| Invitro | HUP30 抑制苯肾上腺素诱导的主动脉收缩，IC50 值为 3.9 μM[1]。HUP30 (100 μM) 增加去氧肾上腺素刺激的主动脉中的 cGMP 水平[1]。HUP30 对 25/30 mM K+ 收缩的大鼠主动脉环产生解痉作用，IC50 值为 7.5 μM[1] .HUP30 (3-100 μM) 抑制苯肾上腺素诱导的细胞外 Ca2+ 内流和 Ca2+ 动员[1]。HUP30 (10-100 μM) 抑制单尾动脉肌细胞中的电流[1]。 | ||||||||||||
| Name | HUP30 | ||||||||||||
| CAS | 312747-21-0 | ||||||||||||
| Formula | C14H15N3O3S | ||||||||||||
| Molar Mass | 305.35 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Fusi F, et al. 2-Aryl- and 2-amido-benzothiazoles as multifunctional vasodilators on rat artery preparations. Eur J Pharmacol. 2013 Aug 15;714(1-3):178-87. |