FXa-IN-1

CAS: 441328-10-5 F: C24H18F5N5O W: 487.42

FXa-IN-1 is a FXa inhibitor (IC50: 3 nM, Ki: 0.7 nM) with respectable oral bioavailability and half-life in vivo. FXa-IN

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Bioactivity	FXa-IN-1 is a FXa inhibitor (IC50: 3 nM, Ki: 0.7 nM) with respectable oral bioavailability and half-life in vivo. FXa-IN-1 can be used for thromboembolic disorders[1].
Target	FXa
In Vivo	FXa-IN-1 (compound 22, rats) exhibits good oral bioavailability (F%: 46.9) and half-life (t1/2: 8.8 h, i.v.)[1].
Name	FXa-IN-1
CAS	441328-10-5
Formula	C24H18F5N5O
Molar Mass	487.42
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zhaozhong J Jia, et al. 1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1229-34.