| Bioactivity | HSV-1-IN-1 (compound 1b) is a drug candidate for herpes simplex virus HSV-1(IC50=0.5 nM) and HSV-2(IC50=16 nM) infection. HSV-1-IN-1 inhibits the helicase-primase complex to prevent viral replication, thereby inhibiting HSV infection[1]. |
| Formula | C21H19F2N3O3S2 |
| Molar Mass | 463.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gege C, et al. Replacement of sulfonamide by sulfoximine within a helicase-primase inhibitor with restricted flexibility[J]. Bioorganic & Medicinal Chemistry Letters, 2024: 129761. |