| Bioactivity | Esuprone is a brain-penetrant, orally active and selective MAO A inhibitor with an IC50 of 7.3 nM. Esuprone can be used for neurological research[1][2]. |
| In Vivo | Esuprone (20 mg/kg, 口服, 2 h) 显著提高大鼠后放电阈值 (ADT)，比对照组高 130%[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 91406-11-0 |
| Formula | C13H14O5S |
| Molar Mass | 282.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Löscher W, et al. Inhibition of monoamine oxidase type A, but not type B, is an effective means of inducing anticonvulsant activity in the kindling model of epilepsy. J Pharmacol Exp Ther. 1999 Mar;288(3):984-92. [2]. Bergström M, et al. MAO-A inhibition in brain after dosing with esuprone, moclobemide and placebo in healthy volunteers: in vivo studies with positron emission tomography. Eur J Clin Pharmacol. 1997;52(2):121-8. |