| Bioactivity | HSP70-IN-4 (Compound YM-01) is an Hsp70 inhibitor with an IC50 of 3.2 μM. HSP70-IN-4 is not BBB permeable[1]. |
| Invitro | HSP70-IN-4 (Compound YM-01; 50 μM) 显著增强 Hsp70 与错误折叠蛋白的结合[1]。HSP70-IN-4 (0-30 μM; 72 h) 抑制 MDA-MB-231、MCF10A 和 MCF7 的活性，EC50 分别为 2.0 ± 0.2、3.3 ± 0.3 和 5.2 ± 0.8 μM[1]。HSP70-IN-4 在水中稳定 (室温下至少 8 小时)[1]。HSP70-IN-4 在人肝微粒体中被快速代谢 (t1/2 值为 ~2-4 min)[1]。 Cell Viability Assay[1] Cell Line: |
| In Vivo | HSP70-IN-4 (Compound YM-01) 不能通过血脑屏障[1]。 Animal Model: |
| Name | HSP70-IN-4 |
| CAS | 1427450-47-2 |
| Formula | C27H27N3O4S3 |
| Molar Mass | 553.72 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Miyata Y, et al. Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. ACS Chem Neurosci. 2013 Jun 19;4(6):930-9. |