| Bioactivity | ZAPA sulfate is an agonist at low affinity GABAA-receptors. ZAPA sulfate induces membrane hyperpolarization of the Ascaris muscle cell with an EC50 of 10.3 μM[1][2]. |
| Invitro | 局部应用 ZAPA (100 μM) sulfate 可瞬时增加 [Ca2+]i，与 GABA 诱发的反应相似[1]。 |
| Name | ZAPA sulfate |
| CAS | 371962-01-5 |
| Formula | C4H8N2O6S2 |
| Molar Mass | 244.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yokogawa T, et al. Analysis of GABAA‐and GABAB‐receptor mediated effects on intracellular Ca2+ in DRG hybrid neurones. British journal of pharmacology, 2001, 134(1): 98-107. [2]. Holden-Dye L, et al. ZAPA, (Z)-3-[(aminoiminomethyl)thio]-2-propenoic acid hydrochloride, a potent agonist at GABA-receptors on the Ascaris muscle cell. Br J Pharmacol. 1988 Sep;95(1):3-5. |
ZAPA sulfate
CAS: 371962-01-5 F: C4H8N2O6S2 W: 244.25
ZAPA sulfate is an agonist at low affinity GABAA-receptors. ZAPA sulfate induces membrane hyperpolarization of the Ascar
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