| Bioactivity | HSDVHK-NH2 TFA is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC50 of 1.74 pg/mL (2.414 pM)[1][2]. |
| Invitro | HSDVHK significantly inhibited bFGF-induced cell migration compared to the PBS control group[1].The Arg-Gly-Asp (RGD)-binding site recognition by HSDVHK-NH2 (P11) is site specific because the HSDVHK-NH2 (P11) is inactive for the complex formation of a denatured form of integrin–vitronectin. HSDVHK-NH2 (P11) shows a strong antagonism against avb3-GRGDSP interaction with an IC50 value of 25.72 nM[2].HSDVHK-NH2 (P11) inhibits the HUVEC proliferation due to the induction of HUVEC cell death through caspases activations and its mechanism is related with increased p53 expression[3]. Cell Proliferation Assay[3] Cell Line: |
| Name | HSDVHK-NH2 TFA |
| Shortening | HSDVHK-NH2 |
| Formula | C32H49F3N12O11 |
| Molar Mass | 834.80 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |