| Bioactivity | HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor with Ki values of 0.26, 0.208, 2.94, and ＞100 μM for DAPK3, Pim-3, Pim-1, and Pim-2, respectively. HS56 inhibits LC20 phosphorylation and smooth muscle contraction. HS56 decreases blood pressure in spontaneously hypertensive mice. HS56 can be used in research of hypertension[1]. |
| Invitro | HS56 (50 μM; 16 h) 延迟离体大鼠尾动脉 VSM 组织中的力开始，降低收缩力，并降低 LC20 磷酸化[1]。 Western Blot Analysis[1] Cell Line: |
| In Vivo | HS56 (10 and 20 mg/kg; i.v.; 单次注射) 降低自发性高血压小鼠的血压 (BP)[1]。 Animal Model: |
| Name | HS56 |
| CAS | 922050-57-5 |
| Formula | C13H8ClN5OS |
| Molar Mass | 317.75 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Carlson DA, et, al. Targeting Pim Kinases and DAPK3 to Control Hypertension. Cell Chem Biol. 2018 Oct 18;25(10):1195-1207.e32. |