| Bioactivity | HS271 is a highly potent, orally active and selective IRAK4 inhibitor, with an IC50 of 7.2 μM. HS271 exhibits superior enzymatic and cellular activities, as well as excellent pharmacokinetic properties[1]. | ||||||||||||
| In Vivo | HS271 (15-150 mg/kg) displays robust in vivo antiinflammatory efficacy as evaluated in rat models of LPS induced TNFα production collageninduced arthritis[1].HS271 exhibits a t1/2 of 3.3 h and Cmax of 2107 ng/mL[1].HS271 is stable in liver microsome assays across other species, including rat, mouse, monkey, and human[1].HS271 exhibits oral bioavailability of 67.3%, 58.2%, 14.4&% and 49% in mouse, rat, dog and monkey, respectively[1]. Animal Model: | ||||||||||||
| Name | HS271 | ||||||||||||
| CAS | 2410393-15-4 | ||||||||||||
| Formula | C21H24F3N5O2 | ||||||||||||
| Molar Mass | 435.44 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Wenqiang Zhai, et al. Discovery and optimization of a potent and selective indazolamine series of IRAK4 inhibitors. Bioorg Med Chem Lett. 2020 Nov 24;31:127686. |
HS271
CAS: 2410393-15-4 F: C21H24F3N5O2 W: 435.44
HS271 is a highly potent, orally active and selective IRAK4 inhibitor, with an IC50 of 7.2 μM. HS271 exhibits superior
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