| Bioactivity | AA-T3A-C12 is an anisamide ligand-tethered lipidoid (AA-lipidoid). AA-T3A-C12 mediates great RNA delivery and transfection of activated fibroblasts[1]. |
| Invitro | AA-T3A-C12/siRNA LNP 可增强 TGF-β 刺激的 3T3 成纤维细胞对 siRNA LNP 的摄取[1]。AA-T3A-C12 LNP 可在活化的成纤维细胞中实现较强的基因敲低[1]。 |
| In Vivo | AA-T3A-C12/siHSP47 LNP (siRNA 剂量为 5 μg/小鼠，静脉注射，每周两次，持续 2 周) 显着下调纤维化小鼠中的 HSP47 表达[1]。 Animal Model: |
| Name | AA-T3A-C12 |
| Formula | C65H126N4O6 |
| Molar Mass | 1059.72 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Han X, et al. Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis. Nat Commun. 2023 Jan 17;14(1):75. |