| Bioactivity | HJ-PI01 (10-Acetylphenoxazine) is an orally active Pim-2 inhibitor. HJ-PI01 induces apoptosis and autophagic cell death of cancer cells. HJ-PI01 inhibits tumor growth in MDA-MB-231 xenograft mice. HJ-PI01 can be used for cancer research[1]. |
| Invitro | HJ-PI01 (0-3200 nmol/L；48 小时) 剂量性依赖地抑制 MDA-MB-231 细胞生长，与氯丙嗪和 PI003 相比效果更为显著改善[1]。HJ-PI01 (100-400 nmol/L；24 小时) 对正常非癌细胞显示弱毒性[1]。HJ-PI01 (300 nmol/L；24 小时) 诱导 MDA-MB-231 细胞自噬性细胞死亡[1]。HJ-PI01 (300 nmol/L；24 小时) 诱导 MDA-MB-231 细胞凋亡性死亡[1]。HJ-PI01 (300 和 460 nmol/L；12-48 小时) 影响自噬和凋亡相关蛋白的表达水平[1]。 Western Blot Analysis[1] Cell Line: |
| In Vivo | HJ-PI01 (40 mg/kg；口服，每日 1 次，持续 10 天) 抑制 MDA-MB-231 异种移植小鼠肿瘤生长[1]。 Animal Model: |
| Name | HJ-PI01 |
| CAS | 6192-43-4 |
| Formula | C14H11NO2 |
| Molar Mass | 225.24 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhao YQ, et al. Characterization of HJ-PI01 as a novel Pim-2 inhibitor that induces apoptosis and autophagic cell death in triple-negative human breast cancer. Acta Pharmacol Sin. 2016 Sep;37(9):1237-50. |