| Bioactivity | HIV-1 inhibitor-44 (compound 11l) is a HIV-1 reverse transcriptase inhibitor. HIV-1 inhibitor-44 shows inhibitory activity against wild-type HIV-1 strain with an EC50 value of 0.209 μM[1]. |
| Invitro | HIV-1 inhibitor-44 (compound 11l) displays potent inhibitory activity against WT HIV-1, mutant strains L100I and E138K, with EC50s of 0.21 μM, 0.94 μM, and 1.37 μM, respectively[1]. |
| Name | HIV-1 inhibitor-44 |
| Formula | C23H26N2O4S |
| Molar Mass | 426.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hao Q, et al. Structure-Based design of [(2-Hydroxyethoxy)methyl]-6-(phenylthio)-thymine derivatives as nonnucleoside HIV-1 reverse transcriptase Inhibitors: From HEPTs to Sulfinyl-substituted HEPTs. Bioorg Chem. 2022 Sep. 126:105880. |