HIF-2α-IN-8

CAS: 2734922-78-0 F: C17H11ClF7N3O W: 441.73

HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC50 values of 9, 37, 246 nM for HIF2α SPA, HIF2α iSc

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Bioactivity	HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC50 values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity[1].
Target	IC50: 9 nM (HIF2α SPA); 37 nM (HIF2α iScript); 246 nM (HIF2α HRE RGA)
In Vivo	HIF-2α-IN-8 (Example 31) (30 mg/kg; p.o.; daily for 21 days) 在小鼠体内显示出抗肿瘤活性[1]。 Animal Model:
Name	HIF-2α-IN-8
CAS	2734922-78-0
Formula	C17H11ClF7N3O
Molar Mass	441.73
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Robin Alec Fairhurst, et al. Compounds and compositions for inhibiting the activity of hif2-alpha and their methods of use. WO2021220170A1.