HIF-1 inhibitor-4_product_DataBase

CAS: 333357-56-5 F: C18H19IN2O2 W: 422.26

HIF-1 inhibitor-4 is a HIF-1 inhibitor (IC50: 560 nM). HIF-1 inhibitor-4 reduces the HIF-1α protein level without affec

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	HIF-1 inhibitor-4 is a HIF-1 inhibitor (IC50: 560 nM). HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level[1].
Invitro	HIF-1 inhibitor-4 (Compound 1) 抑制 HIF-1，IC50 为 560 nM (使用 U251 细胞进行定量，在 VEGF 启动子 (VEGF-PLAP) 的控制下表达 PLAP 报告基因)[1]。
Name	HIF-1 inhibitor-4
CAS	333357-56-5
Formula	C18H19IN2O2
Molar Mass	422.26
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Nagao S, et al. Synthesis and structure-activity relationships of novel, potent, orally active hypoxia-inducible factor-1 inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5513-29.

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