| Bioactivity | BAY-805 is a selective inhibitor of ubiquitin-specific protease USP21. BAY-805 has high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases and other common target enzymes[1]. |
| Target | USP21 |
| Invitro | BAY-805 抑制 hUSP21 HTRF 和 hUSP21 Ub-Rhod 的活性，IC50 值分别为 6 nM 和 2 nM[1]。BAY-805 (10 µM) 诱导 NF-κB 活化，EC50 值为 17 nM[1]。BAY-805 (10 µM 和 50 µM) 显著抑制 USP21 的活性，对 USP22 和 USP10 也展现出微弱的抑制作用[1]。BAY-805 (0.0001-1000000 nM) 选择性的抑制 USP21 的活性[1]。 |
| Name | BAY-805 |
| Formula | C24H28F3N5O2S |
| Molar Mass | 507.57 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| Reference | [1]. Göricke F, et al. Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21. J Med Chem. 2023 Feb 20. |