| Bioactivity | HHS-0701, a sulfur-triazole exchange (SuTEx) ligand, is a potent tyrosine-reactive prostaglandin reductase 2 (PTGR2) inhibitor. HHS-0701 blocks PTGR2 metabolism of the lipid substrate 15-Keto-PGE2[1]. | ||||||||||||
| Invitro | HHS-0701 (0.1, 0.25, 0.5, 1, 2.5, 5, 10, 25 μM; 2 小时) 在处理重组 PTGR2 过表达 HEK293T 细胞时导致浓度依赖性探针标记阻断[1] . | ||||||||||||
| Name | HHS-0701 | ||||||||||||
| CAS | 2851993-91-2 | ||||||||||||
| Formula | C20H20N4O3S | ||||||||||||
| Molar Mass | 396.46 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Emmanuel K Toroitich, et al.Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. |
HHS-0701
CAS: 2851993-91-2 F: C20H20N4O3S W: 396.46
HHS-0701, a sulfur-triazole exchange (SuTEx) ligand, is a potent tyrosine-reactive prostaglandin reductase 2 (PTGR2) inh
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