| Bioactivity | HER2-IN-19 (Compound 10e) is a potent inhibitor of HER2 and EGFR with IC50 values of 0.87 respectively and 3.5 nM. HER2-IN-19 has potent inhibitory activity against tumor cells, IC50NCI-N87 = 1.63 nM, IC50BT474= 15.17 nM, IC50BaF3-HER2YVMA = 1.49 nM[1]. |
| Formula | C30H29ClN6O2 |
| Molar Mass | 541.04 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yang L, et al. Discovery of Novel 5,6-Dihydro-4H-pyrido[2,3,4-de]quinazoline Irreversible Inhibitors Targeting Both Wild-Type and A775_G776insYVMA Mutated HER2 Kinases. J Med Chem. 2024 Apr 11;67(7):5662-5682. |