PeptideDB

Poneratoxin

CAS: 137084-94-7 F: C129H215N33O31S W: 2756.35

Poneratoxin is a peptide toxin, which regulates the sodium currents in mammalian, and causes long-lasting pain.
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Bioactivity Poneratoxin is a peptide toxin, which regulates the sodium currents in mammalian, and causes long-lasting pain[1].
In Vivo Poneratoxin 在 C57BL/6 J 小鼠模型中引起立即和持久的伤害行为 (20 至 600 pmol,足底注射,单剂量),并在苍蝇模型中导致麻痹,PD50 (1 h) 为 74.3 nmol /g (0-100 nmol/g,腹腔注射,单剂量)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS 137084-94-7
Sequence Phe-Leu-Pro-Leu-Leu-Ile-Leu-Gly-Ser-Leu-Leu-Met-Thr-Pro-Pro-Val-Ile-Gln-Ala-Ile-His-Asp-Ala-Gln-Arg-NH2
Shortening FLPLLILGSLLMTPPVIQAIHDAQR-NH2
Formula C129H215N33O31S
Molar Mass 2756.35
Transport Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Reference [1]. Robinson SD, et al., Ant venoms contain vertebrate-selective pain-causing sodium channel toxins. Nat Commun. 2023 May 23;14(1):2977.