| Bioactivity | HDAC6-IN-43 (compound 26) is a potent HDAC inhibitor. HDAC6-IN-43 effectively inhibits several HDACs, notably HDAC1, HDAC2, and HDAC6 (IC50 < 150 nM), displaying a particularly high sensitivity towards HDAC6 (IC50 = 11 nM). HDAC6-IN-43 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD)[1]. |
| Invitro | HDAC6-IN-43 (compound 26) 通过上调 α-微管蛋白乙酰化水平显着抑制 Madin-Darby 犬肾 (MDCK) 细胞的生长和增殖[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> HDAC6-IN-43 相关抗体: |
| Formula | C21H24N2O4S |
| Molar Mass | 400.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cao X, et al. Benzothiazole derivatives as histone deacetylase inhibitors for the treatment of autosomal dominant polycystic kidney disease. Eur J Med Chem. 2024 May 5;271:116428. |