| Bioactivity | HDAC6-IN-14 is a highly selective HDAC6 (HDAC) inhibitor with an IC50 of 42 nM. HDAC6-IN-14 displays >100-fold selectivity over HDAC1/HDAC2/HDAC3/HDAC4[1]. |
| Invitro | HDAC6-IN-14 (compound 10p; 1-5 μM; 48 h) treatment results in a significant apoptosis induction in HL60 cells[1].HDAC6-IN-14 (compound 10p; 6-36 μM; 24 h) treatment induces acetylation of α-tubulin but has no effect on Ac-H3 levels even at concentrations of ≤36 μM in HL60 cells[1]. Apoptosis Analysis[1] Cell Line: |
| Name | HDAC6-IN-14 |
| Formula | C24H30FN3O4 |
| Molar Mass | 443.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nina Reßing, et al. Development of Fluorinated Peptoid-Based Histone Deacetylase (HDAC) Inhibitors for Therapy-Resistant Acute Leukemia. J Med Chem. 2022 Nov 24;65(22):15457-15472. |