HDAC-IN-73_product_DataBase

Bioactivity	HDAC-IN-73 (compound p-503) is a potent HDAC inhibitor with IC50 values of 0.17, 0.49 µM for HDAC1 and HDAC6, respectively. HDAC-IN-73 induces apoptosis and cell cycle arrest at the G2/M phase. HDAC-IN-73 shows anti-tumor activity[1].
Invitro	HDAC-IN-73 (compound p-503) (0-2 µM; 24 h) 可增加 HCT116 细胞中 Ac-α-微管蛋白和 Ac-H3 的蛋白表达[1]。HDAC-IN-73 (0.1-0.4 µM) 可诱导细胞凋亡和细胞周期停滞于 G2/M 期[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> HDAC-IN-73 相关抗体: Cell Proliferation Assay[1] Cell Line:
In Vivo	HDAC-IN-73 (5 mg/kg; i.p.; every 2 days for 26 days) 可抑制 HCT116 异种移植模型中的肿瘤生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	2323571-16-8
Formula	C22H24Br2N4O6Se2
Molar Mass	758.18
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Jiang Y, et al. Psammaplin A analogues with modified disulfide bond targeting histone deacetylases: Synthesis and biological evaluation. Eur J Med Chem. 2024 May 31;275:116541.

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