| Bioactivity | HCAR2 agonist 1 (Compound 9n) is a Gi protein-biased allosteric modulator of HCAR2. HCAR2 agonist 1 activates the Gi protein signaling pathway. HCAR2 agonist 1 shows anti-inflammatory effect, and reduces mRNA level of pro-inflammatory cytokine (TNF-α, IL-1β, IL-6, and MCP-1). HCAR2 agonist 1 enhances anti-inflammatory effects of orthosteric agonists in the mouse model of colitis[1]. |
| Name | HCAR2 agonist 1 |
| CAS | 1066676-21-8 |
| Formula | C26H28N4O2 |
| Molar Mass | 428.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhao C, et al. Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation. Mol Cell. 2023 Sep 7;83(17):3171-3187.e7. |
HCAR2 agonist 1
CAS: 1066676-21-8 F: C26H28N4O2 W: 428.53
HCAR2 agonist 1 (Compound 9n) is a Gi protein-biased allosteric modulator of HCAR2. HCAR2 agonist 1 activates the Gi pro
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