| Bioactivity | HBV-IN-30 (ex44), a flavone derivative, is a potent covalently closed circular DNA (cccDNA) inhibitor. cccDNA serves as the template for viral RNA transcription and subsequent viral DNA generation. HBV-IN-30 has the potential for the research of HBV infection[1]. |
| Invitro | HBV-IN-30 (ex44; 24 h) 在 HepDES19 细胞中抑制 HBeAg 水平和细胞活力，IC50 值为 0.57 μM。HepDES19 是产生 cccDNA 的细胞系[1]。HBV-IN-30 (5 天) 以剂量依赖性方式降低 HepDES19 细胞中的 cccDNA 水平[1]。HBV-IN-30 (9 天; 原代人肝细胞 (PHH)) 具有抗 HBV 作用并抑制 HBeAg，IC50 值为 0.04 μM[1]。 |
| Name | HBV-IN-30 |
| CAS | 2413192-92-2 |
| Formula | C22H18BrClO6 |
| Molar Mass | 493.73 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Song F, et, al. Flavone compounds for the treatment and prophylaxis of hepatitis b virus disease. WO2020053249. |
HBV-IN-30
CAS: 2413192-92-2 F: C22H18BrClO6 W: 493.73
HBV-IN-30 (ex44), a flavone derivative, is a potent covalently closed circular DNA (cccDNA) inhibitor. cccDNA serves as
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This product is for research use only, not for human use. We do not sell to patients.