| Bioactivity | GrTx1 is a peptide toxin originally isolated from the venom of the spider Grammostola rosea. GrTx1 blocks sodium channel， with IC50s of 0.63 µM, 0.23 µM, 0.77 µM, 1.29 µM, 0.63 µM and 0.37 µM for Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7, repectively[2].GrTx1 can be used for neurological disease research[1]. |
| Invitro | GrTx1 (0-100 μΜ, 3 分钟) 能阻断神经母细胞瘤 F-11 细胞的 Na+ 电流，IC50 值为 2.8 μM[1]。GrTx1 (0-100 μΜ, 3 分钟) 能阻断神经母细胞瘤 F-11 细胞约 85% 的 Na+ 电流，对常见的 K+ 通道如 Kv1.1 和 1.4 没有影响[1]。 |
| Name | GrTx1 |
| Sequence | Tyr-Cys-Gln-Lys-Trp-Met-Trp-Thr-Cys-Asp-Ser-Lys-Arg-Lys-Cys-Cys-Glu-Asp-Met-Val-Cys-Gln-Leu-Trp-Cys-Lys-Lys-Arg-Leu (Disulfide bonds: Cys2-Cys16, Cys9-Cys21, Cys15-Cys25) |
| Shortening | YCQKWMWTCDSKRKCCEDMVCQLWCKKRL (Disulfide bonds: Cys2-Cys16, Cys9-Cys21, Cys15-Cys25) |
| Formula | C159H243N45O41S8 |
| Molar Mass | 3697.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Clement H,et.al. Isolation and characterization of a novel toxin from the venom of the spider Grammostola rosea that blocks sodium channels. Toxicon. 2007 Jul;50(1):65-74. [2]. Redaelli E, et.al. Target promiscuity and heterogeneous effects of tarantula venom peptides affecting Na+ and K+ ion channels. J Biol Chem. 2010 Feb 5;285(6):4130-4142. |