| Bioactivity | CaSRantagonist-1 is a calcium sensing receptor (CaSR) antagonistwith an IC50 value of 50 nM. CaSRantagonist-1 can be used for the research of disorders associated with abnormalbone or mineral homeostasis such as osteoporosis[1]. |
| Target | IC50:50 nM (CaSR).EC50:＞50 μM (hPXR Gene reporter assay). |
| Name | CaSR antagonist-1 |
| CAS | 1219811-83-2 |
| Formula | C29H24FN3O2S |
| Molar Mass | 497.58 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ramanjulu JM, et al. Overcoming the Pregnane XReceptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction.ACS Med Chem Lett. 2021 Aug 10;12(9):1396-1404. |
CaSR antagonist-1
CAS: 1219811-83-2 F: C29H24FN3O2S W: 497.58
CaSRantagonist-1 is a calcium sensing receptor (CaSR) antagonistwith an IC50 value of 50 nM. CaSRantagonist-1 can be use
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