| Bioactivity | Glycolate oxidase-IN-1(compound 26), a salicylic acid derivative, is a glycolate oxidase (GO) inhibitor with an IC50 of 38.2 μM. Glycolate oxidase-IN-1 has the ability to reduce oxalate production in hyperoxalate hepatocytes and can be used in the study of primary hyperoxaluria type 1 (PH1)[1]. |
| Invitro | Glycolate oxidase-IN-1(compound 26)(0-12.5 μM, 48 h)处理小鼠肝细胞，在浓度为 6.25 μM 时，排出的草酸盐水平显着降低 67.3 ± 32%。在 12.5 μM 的浓度下，处理 24 小时和 48 小时后分别减少105.8 ± 29.2% 和 62.3 ± 24.4%，且没有任何细胞毒性[1]。 |
| Name | Glycolate oxidase-IN-1 |
| CAS | 330977-65-6 |
| Formula | C12H8O5 |
| Molar Mass | 232.19 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. María Dolores Moya-Garzón, et al. Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1. J Med Chem. 2018 Aug 23;61(16):7144-7167. |
Glycolate oxidase-IN-1
CAS: 330977-65-6 F: C12H8O5 W: 232.19
Glycolate oxidase-IN-1(compound 26), a salicylic acid derivative, is a glycolate oxidase (GO) inhibitor with an IC50 of
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