| Bioactivity | Glyco-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is a farnesoid X receptor (FXR) agonist[1]. | ||||||||||||
| Invitro | Obeticholic acid is conjugated with glycine in the liver to form glycol-obeticholic acid, which is secreted into bile. Microorganisms in the ileum and colon can deconjugate glyco-obeticholic acid, converting it into the parent drug, which may then be reabsorbed or excreted in faeces[1]. | ||||||||||||
| Name | Glyco-Obeticholic acid | ||||||||||||
| CAS | 863239-60-5 | ||||||||||||
| Formula | C28H47NO5 | ||||||||||||
| Molar Mass | 477.68 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Markham A, et al. Obeticholic Acid: First Global Approval. Drugs. 2016 Aug;76(12):1221-6. |
Glyco-Obeticholic acid
CAS: 863239-60-5 F: C28H47NO5 W: 477.68
Glyco-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is a farnesoid X receptor (FXR) ago
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