Olanexidine_product_DataBase

Bioactivity	Olanexidine is an antibacterial agent. Olanexidine is active against a wide range of bacteria, imcluding both Gram-positive and Gram-negative bacteria Olanexidine is also an antiseptic. Olanexidine can be used in the research of infection and inflammation[1][2][3].
Invitro	Olanexidine (50 μM, 48 h) exhibits broad-spectrum bactericidal activity against Gram-positive cocci and Gram-negative bacteria[1].Olanexidine (50 μg/mL, 24 h) inhibits chronic inflammatory reactions in oral mucosal cells[2].Olanexidine (Olanexidine gluconate, 0-15000 μg/mL) inhibits the binding ability of virus-like particles to the binding receptor of human norovirus and increases the aggregation of virus-like particles[3]. Cell Viability Assay[1] Cell Line:
In Vivo	Olanexidine (1 -2% in saline, applied to the skin) is active against transient or resident bacterial flora on the skin of male cynomolgus monkeys[4]. Animal Model:
Name	Olanexidine
CAS	146510-36-3
Formula	C17H27Cl2N5
Molar Mass	372.34
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Hagi A, et al. Bactericidal Effects and Mechanism of Action of Olanexidine Gluconate, a New Antiseptic. Antimicrob Agents Chemother. 2015 Aug;59(8):4551-9. [2]. Nii T, Yumoto H, Hirota K, Miyake Y. Anti-inflammatory effects of olanexidine gluconate on oral epithelial cells. BMC Oral Health. 2019 Nov 8;19(1):239. [3]. Imai K, et al. Disinfection efficacy and mechanism of olanexidine gluconate against norovirus. Am J Infect Control. 2022 Jul;50(7):764-771. [4]. Nakata H, et al. Effects of olanexidine gluconate on preoperative skin preparation: an experimental study in cynomolgus monkeys. J Med Microbiol. 2017 May;66(5):678-685.

PeptideDB

Olanexidine

CAS: 146510-36-3 F: C17H27Cl2N5 W: 372.34