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Glucosylceramide synthase-IN-4

Bioactivity Glucosylceramide synthase-IN-4 (compound 12) is a potent glucosylceramide synthase (GCS) inhibitor, with an IC50 of 6.8 nM. Glucosylceramide synthase-IN-4 shows excellent PK properties and stability in human hepatocytes. Glucosylceramide synthase-IN-4 has good CNS penetration and acceptable PXR selectivity[1].
Name Glucosylceramide synthase-IN-4
CAS 2776965-41-2
Formula C22H18F5N3O3
Molar Mass 467.39
Transport Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Reference [1]. H. Marie Loughran, et al. Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections. ACS Med. Chem. Lett. 2024, 15, 1, 123-131.

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