Glucocorticoid receptor agonist-2_product_DataBase

Bioactivity	Glucocorticoid receptor agonist-2 (compound 21) is an glucocorticoid receptor agonist with an IC50 value of 6.6 nM. Glucocorticoid receptor agonist-2 can be used to synthesize anti-inflammatory ADC molecules. Glucocorticoid receptor agonist-2 is an active reference of ABBV-3373[1].
Invitro	Glucocorticoid receptor agonist-2 对糖皮质激素受体 (GR) 和孕激素受体 (PR) 结合的 IC50 值分别为 6.6 和 7.3 nM[1]。Glucocorticoid receptor agonist-2 对糖皮质激素效应元件 (GRE) 报告基因和盐皮质激素受体 (MR) 的 EC50 值分别为 0.2 和 442 nM[1]。Glucocorticoid receptor agonist-2 对盐皮质激素受体激动活性的 EC50 值为 149 nM[1]。
Name	Glucocorticoid receptor agonist-2
CAS	2166378-92-1
Formula	C34H35F2NO7
Molar Mass	607.64
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reference	[1]. Mcpherson MJ, et al. Preparation of glucocorticoid receptor agonist and immunoconjugates thereof. WO2017210471. 2017.

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