| Bioactivity | Genkwadaphnin is a daphnane diterpenoid, targeting of importin-β1 to reduce the nuclear accumulation of key CRPC drivers, and shut down their downstream oncogenic signaling. Genkwadaphnin shows potent anti-tumor activity and inhibits castration-resistant prostate cancer (CRPC) in vivo in mice[1]. |
| Target | Importin-β1 |
| Name | Genkwadaphnin |
| CAS | 55073-32-0 |
| Formula | C34H34O10 |
| Molar Mass | 602.63 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Huang JL, et al. Discovery of Highly Potent Daphnane Diterpenoids Uncovers Importin-β1 as a Druggable Vulnerability in Castration-Resistant Prostate Cancer. J Am Chem Soc. 2022 Sep 14. |
Genkwadaphnin
CAS: 55073-32-0 F: C34H34O10 W: 602.63
Genkwadaphnin is a daphnane diterpenoid, targeting of importin-β1 to reduce the nuclear accumulation of key CRPC driver
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