| Bioactivity | GeX-2 is a truncated analogue of αO-conotoxin. GeX-2 activates GABAB receptor. GeX-2 inhibits α9α10 nAChR and CaV2.2 channels. GeX-2 alleviates pain in the rat model of chronic constriction injury[1]. |
| CAS | 2900996-95-2 |
| Sequence | GRYRSPYDRRRRYRRITD-NH2 |
| Shortening | Gly-Arg-Tyr-Arg-Ser-Pro-Tyr-Asp-Arg-Arg-Arg-Arg-Tyr-Arg-Arg-Ile-Thr-Asp-NH2 |
| Formula | C103H169N43O27 |
| Molar Mass | 2441.72 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li X, et al. Dual Antagonism of α9α10 nAChR and GABAB Receptor-Coupled CaV2.2 Channels by an Analgesic αO-Conotoxin Analogue. J Med Chem. 2024 Jan 25;67(2):971-987. |