| Bioactivity | GePhos1, a EGFR-targeting PhosTAC (phosphorylation targeting chimera), induces EGFR dephosphorylation. GePhos1 induces apoptosis[1]. |
| Invitro | GePhos1 在EGFR的pY1068位点和pY845位点上显示出显著的EGFR去磷酸化作用，其中pY1068是EGFR主要的自磷酸化位点之一，pY845是激酶环内的关键位点[1]。GePhos1 (1 μM) 在HeLa细胞中诱导凋亡和细胞死亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> GePhos1 相关抗体: |
| Formula | C63H75ClFN7O13 |
| Molar Mass | 1192.76 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhenyi Hu, et al. EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling. Sci Adv. 2024 Mar 29;10(13):eadj7251. |