Galectin-3-IN-4_product_DataBase

Bioactivity	Galectin-3-IN-4 (compound 5) is a carboxamide analog. Galectin-3-IN-4 is a potent, selective, and orally bioavailable inhibitor of human and mouse galectin-3, with IC50 values of 21 and 167 nM for hGal-3 and mGal-3, respectively. Galectin-3-IN-4 has IC50 values of 1580 and 2750 nM for hGal-1 and hGal-9, respectively[1].
In Vivo	Galectin-3-IN-4 (compound 5) (2 mg/kg IV, 10 mg/kg PO; once) 具有低清除率 (CL=12 mL/min/kg) 和高分布容积 (Vss=2.1 L/kg），小鼠口服生物利用度为 52%[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	2496515-38-7
Formula	C24H22ClF2N5O5S
Molar Mass	565.98
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Liu C, et al. Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S···O binding interaction for drug design. Bioorg Med Chem. 2024 Mar 1;101:117638.

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