FKBP51-Hsp90-IN-2_product_DataBase

Bioactivity	FKBP51-Hsp90-IN-2 (Compound E08) is a selective FKBP51-Hsp90 protein-protein interaction inhibitor with IC50 values of 0.4 µM and 5 µM for FKBP51 and FKBP52, respectively. FKBP51-Hsp90-IN-2 also effectively stimulates cellular energy metabolism and neurite growth. FKBP51-Hsp90-IN-2 can be used in research on neurodegenerative diseases and cancer[1].
Target	IC50: 0.4 µM (FKBP51); 5 µM (FKBP52).
Invitro	FKBP51-Hsp90-IN-2 (3-30 μM; 48 h) 在 HEK293 细胞中抑制 Hsp90 与 FKBP51 的结合[1]。FKBP51-Hsp90-IN-2 (10 μM; 1-4 h) 增加 HEK293 细胞能量代谢[1]。FKBP51-Hsp90-IN-2 刺激分化神经母细胞瘤 SH-SY5Y 细胞中的神经突生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> FKBP51-Hsp90-IN-2 相关抗体: Cell Viability Assay[1] Cell Line:
CAS	601511-07-3
Formula	C25H27N3O2S
Molar Mass	433.57
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wang L, et al. Structure-based discovery of small molecule inhibitors of FKBP51-Hsp90 protein-protein interaction. Eur J Med Chem. 2024 Mar 28;270:116356.

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