Galectin-3-IN-3_product_DataBase

Bioactivity	Galectin-3-IN-3 (Compound 4) is an orally active and selective inhibitor of Gal-3, with IC50 values of 11 nM and 84 nM against mGal-3 and hGal-3 respectively[1].
In Vivo	Galectin-3-IN-3 (compound 4) (2 mg/kg; 静脉注射; 单剂量) 在小鼠血浆中具有低清除率 (CL=8 mL/min/kg)、较高的分布体积 (Vss=1.8 L/kg) 和较好的口服生物利用度 (F=40％)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	2491661-50-6
Formula	C25H22ClF2N7O4S
Molar Mass	590.00
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Liu C, et al. Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S···O binding interaction for drug design. Bioorg Med Chem. 2024;101:117638.

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