| Bioactivity | Clovibactin TFA is the TFA salt form of Clovibactin (HY-P10027). Clovibactin TFA is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors[1]. | ||||||
| Invitro | Clovibactin TFA 对葡萄球菌菌株具有抑制活性，MIC 为 0.125-2 μg/mL[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Clovibactin TFA 相关抗体: | ||||||
| In Vivo | Clovibactin TFA (20 mg/kg，静脉注射，单剂量) 在 CD-1 小鼠模型内的药代动力学特征为 Cmax 为 219.3 μg/mL，AUCto last 为 31.9 μg·h/mL，t1/2 为 2 h，CL 为 9.4 mL/kg/min 以及 Vdss 为 189.8 mL/kg[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||
| Sequence | Phe-{d-Leu}-{d-Lys}-Ser-{Hyn}-Ala-Leu-Leu (Cyclic ester: Hyn5-Leu8) | ||||||
| Shortening | F-{d-Leu}-{d-Lys}-S-{Hyn}-ALL (Cyclic ester: Hyn5-Leu8) | ||||||
| Formula | C43H70N10O11.xC2HF3O2 | ||||||
| Molar Mass | 903.08 (free base) | ||||||
| Appearance | 固体 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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| Reference | [1]. Shukla R, et al., A new antibiotic from an uncultured bacterium binds to an immutable target. bioRxiv [Preprint]. 2023 May 15:2023.05.15.540765. |
Clovibactin TFA
CAS: F: C43H70N10O11.xC2HF3O2 W: 903.08 (free base)
Clovibactin TFA is the TFA salt form of Clovibactin (HY-P10027). Clovibactin TFA is an antibiotic for drug-resistant bac
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This product is for research use only, not for human use. We do not sell to patients.