GW 833972A_product_DataBase

Bioactivity	GW 833972A is a selective CB2 receptor agonist. GW 833972A inhibits induced nerve depolarization and citric acid-induced cough in animal models[1].
Invitro	GW 833972A (0.3-300 μM; 10 min) 抑制辣椒素诱导的人和豚鼠去极化，还抑制前列腺素 E(2) 和高渗盐水诱导的豚鼠离体迷走神经去极化[1]。
In Vivo	GW 833972A (30 mg/kg, 2 mL/kg;腹腔注射; 单次剂量, 试验开始前 30 min 注射) 能够抑制柠檬酸诱导的有意识豚鼠的咳嗽症状。它还抑制辣椒素引起的主支气管血浆蛋白渗出现象[1]。
Name	GW 833972A
CAS	1092502-33-4
Formula	C18H14Cl2F3N5O
Molar Mass	444.24
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Belvisi MG, et al. Inhibitory activity of the novel CB2 receptor agonist, GW833972A, on guinea-pig and human sensory nerve function in the airways. Br J Pharmacol. 2008 Oct;155(4):547-57.

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