| Bioactivity | GSK983 is a broad-spectrum antiviral agent. GSK983 inhibits the replication of adenovirus-5 (Ad-5) and polyoma virus SV40. GSK983 inhibits the growth of cell lines immortalized by EBV, HTLV1, HPV. GSK983 induces the expression of interferon-stimulated genes[1]. |
| Invitro | GSK983 (0-10000 nM; 2 h) 抑制原代人成纤维细胞 (HFF) 中腺病毒 5 (Ad-5) 和 Vero 细胞中多瘤病毒 SV40 的复制，中值效应浓度 (K) 分别为 21 nM、7.5 nM； 最大抑制率 (I max) 分别为 99%、88%[1]。GSK983 (0-10000 nM; 72 h) 抑制通过病毒感染永生化的细胞系的生长，对 IM9 (EBV)，B-LCL 5/2/1 ( EBV), MT4 (HTLV1) 细胞的中值效应浓度 (K) 分别为 16, 14, 7.5 nM[1].GSK983 (10, 100 nM; 24, 48 h) 在 W12, HKC 细胞中诱导干扰素刺激基因的表达[1]。 RT-PCR[1] Cell Line: |
| Name | GSK983 |
| CAS | 827591-02-6 |
| Formula | C18H16ClN3O |
| Molar Mass | 325.79 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Harvey R,et al. GSK983: a novel compound with broad-spectrum antiviral activity. Antiviral Res. 2009 Apr;82(1):1-11. |