| Bioactivity | GSK4112 (SR6452) is a Rev-erbα agonist with an EC50 value of 0.4 μM. GSK4112 can be used as a chemical tool to probe the function of Rev-erbα in transcriptional repression, regulation of circadian biology, and metabolic pathways[1]. | ||||||||||||
| Invitro | GSK4112 (0-100 μM; 1 h) interacts with Rev-erbα with an EC50 value of 0.4 μM[1].GSK4112 (10 μM; 6 h) represses expression of bmal1 and the target genes associated with the pathway of gluconeogenesis, recruits HDAC3 and modulates the effect of Rev-erbα on oscillation of hepatic gene expression[1].GSK4112 (10 μM; 16 h) reduces glucose output in murine hepatocytes[1]. RT-PCR[1] Cell Line: | ||||||||||||
| Name | GSK4112 | ||||||||||||
| CAS | 1216744-19-2 | ||||||||||||
| Formula | C18H21ClN2O4S | ||||||||||||
| Molar Mass | 396.89 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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GSK4112
CAS: 1216744-19-2 F: C18H21ClN2O4S W: 396.89
GSK4112 (SR6452) is a Rev-erbα agonist with an EC50 value of 0.4 μM. GSK4112 can be used as a chemical tool to probe t
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