| Bioactivity | GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM. GSK-843 can be used for the research of inflammation[1][2]. | |||||||||
| Invitro | GSK-843 (3-10 μM; 18 h) induces apoptosis[1].GSK-843 (0.3-3 μM; 18 h) suppresses TNF-induced death and virus-induced cell necrosis[2]. Cell Viability Assay[1] Cell Line: | |||||||||
| Name | GSK-843 | |||||||||
| CAS | 1601496-05-2 | |||||||||
| Formula | C19H15N5S2 | |||||||||
| Molar Mass | 377.49 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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