| Bioactivity | AZD1208 is an orally bioavailable, highly selective PIM kinases inhibitor[1]. | ||||||||||||
| Invitro | AZD1208 shows good antiproliferative activity in a megakaryoblastic leukemia cell line, MOLM-16, with GI50 values less than 100 nM[1]. AZD1208 (10 μM) inhibits the growth of Ramos cells, and at 1 μM, strongly inhibits PIM kinases in all cell at 1 μM. AZD1208 induces apoptosis, and PIM2 knockdown is mainly associated with an alteration of the cell cycle[2]. The combination of AZD1208 and AZD2014 rapidly activates AMPKα, a negative regulator of translation machinery through mTORC1/2 signaling in AML cells; profoundly inhibits AKT and 4EBP1 activation; and suppresses polysome formation[3]. | ||||||||||||
| Name | AZD1208 | ||||||||||||
| CAS | 1204144-28-4 | ||||||||||||
| Formula | C21H21N3O2S | ||||||||||||
| Molar Mass | 379.48 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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