| Bioactivity | GPX4-IN-5 (Compound C18) is a GPX4 covalent inhibitor with an IC50 value of 0.12 μM. GPX4-IN-5 (Compound C18) can induce ferroptosis for the research of triple-negative breast cancer (TNBC) [1]. |
| Target | IC50: 0.12 μM (GPX4) |
| Name | GPX4-IN-5 |
| CAS | 2922824-09-5 |
| Formula | C18H17ClFNO5 |
| Molar Mass | 381.78 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chen T, et al. Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2023 Jul 27;66(14):10036-10059. |
GPX4-IN-5
CAS: 2922824-09-5 F: C18H17ClFNO5 W: 381.78
GPX4-IN-5 (Compound C18) is a GPX4 covalent inhibitor with an IC50 value of 0.12 μM.GPX4-IN-5 (Compound C18) can induce
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