| Bioactivity | COX-1/2-IN-5 (compound 2a) is a dual inhibitor of COX1/2 (IC50=2.650 μM, 0.958 μM), with anticancer activity. COX-1/2-IN-5 inhibits liver cancer HepG2 with an IC50 of 60.75 μM[1]. |
| Target | IC50: IC50: 2.650 μM (COX-1), 0.958 μM (COX-2) |
| In Vivo | COX-1/2-IN-5 (compound 2a) |
| Name | COX-1/2-IN-5 |
| Formula | C21H22N2O5S |
| Molar Mass | 414.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hawash M, et al. New Thiazole Carboxamide Derivatives as COX Inhibitors: Design, Synthesis, Anticancer Screening, In Silico Molecular Docking, and ADME Profile Studies. ACS Omega. 2023 Aug 6;8(32):29512-29526. |