| Bioactivity | GPS1573 is a noncompetitive antagonist of melanocortin type 2 receptor (MC2R) that dose-dependently antagonizes ACTH-stimulated MC2R activity (IC50=66 nM). GPS1573 can be used in the study of Cushing's disease due to its highly selective antagonism of MC2R[1]. |
| CAS | 2445822-54-6 |
| Sequence | {Nle}-Pro-{d-Phe}-Arg-{d-Trp}-Phe-Lys-Ala-Val-Gly-Lys-Lys-Arg-Arg-NH2 |
| Shortening | {Nle}-P-{d-Phe}-R-{d-Trp}-FKAVGKKRR-NH2 |
| Formula | C86H138N28O14 |
| Molar Mass | 1788.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bouw E, et al. Development of potent selective competitive-antagonists of the melanocortin type 2 receptor[J]. Molecular and Cellular Endocrinology, 2014, 394(1-2): 99-104. |
GPS1573
CAS: 2445822-54-6 F: C86H138N28O14 W: 1788.20
GPS1573 is a noncompetitive antagonist of melanocortin type 2 receptor (MC2R) that dose-dependently antagonizes ACTH-sti
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