| Bioactivity | GPR40 agonist 5 (compound I-14) is an orally active and potent GPR40 (G protein coupled receptor 40) agonist, with an EC50 of 47 nM. GPR40 agonist 5 decreases the levels of blood glucose and improves the glucose tolerance. GPR40 agonist 5 has sufficient effectiveness for the control of hyperglycemia state in type 2 diabetic mice[1]. |
| Target | EC50: 47 ± 9.8 nM (GPR40) |
| Name | GPR40 agonist 5 |
| CAS | 2443384-60-7 |
| Formula | C27H24N2O4 |
| Molar Mass | 440.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ye Z, et al. Discovery of novel potent GPR40 agonists containing imidazo[1,2-a]pyridine core as antidiabetic agents. Bioorg Med Chem. 2020 Jul 1;28(13):115574. |
GPR40 agonist 5
CAS: 2443384-60-7 F: C27H24N2O4 W: 440.49
GPR40 agonist 5 (compound I-14) is an orally active and potentGPR40 (G protein coupled receptor 40) agonist, with an EC5
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