GPR110 peptide agonist P12_product_DataBase

Bioactivity	GPR110 peptide agonist P12 is a peptide that acts as a GPR110 agonist. GPR110 peptide agonist P12 can significantly enhance the initial rate of GPR110 stimulated G protein GTPγS binding. GPR110 peptide agonist P12 mimics the action of natural ligands, causing the extracellular domain (ECD) of the GPR110 to dissociate from the seven transmembrane domains (7TM), exposing the β-strand-13/stalk region at the N-terminus of the 7TM domain, which acts as an agonist to activate G protein signaling. GPR110 peptide agonist P12 can be used in the study of developmental disorders and cancers related to GPR110[1].
CAS	1778685-49-6
Sequence	Thr-Ser-Phe-Ser-Ile-Leu-Met-Ser-Pro-Phe-Val-Pro
Shortening	TSFSILMSPFVP
Formula	C63H96N12O17S
Molar Mass	1325.57
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Stoveken H M, et al. Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist[J]. Proceedings of the National Academy of Sciences, 2015, 112(19): 6194-6199.

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