| Bioactivity | GNE-886 (Compound 21) is a potent and selective inhibitor of Cat eye syndrome chromosome region candidate 2 bromodomain (CECR2) (BRD) with an IC50 value of 0.016 µM and an EC50 value of 370 nM. GNE-886 also inhibits BRD9 with an IC50 value of 1.6 µM[1]. |
| Target | IC50: 0.016 µM (Cat eye syndrome chromosome region candidate 2 bromodomain, CECR2, BRD) |
| Name | GNE-886 |
| CAS | 2101957-05-3 |
| Formula | C28H30N6O3 |
| Molar Mass | 498.58 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Crawford TD, et al. GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2). ACS Med Chem Lett. 2017 Jun 1;8(7):737-741. |